This issue marks the start of Peter David’s legendary run on The Incredible Hulk. Banner’s fractured psyche begins to take center stage as the tension between man and monster escalates. Following recent experiments and battles, Bruce finds himself under increasing scrutiny by authorities and old enemies alike. Meanwhile, the Leader continues to manipulate events from the shadows, setting the stage for seismic changes to come.

This issue is especially notable for its psychological tone and a shift away from purely smash-and-run storytelling, paving the way for the more complex Gray Hulk and Joe Fixit era. It’s widely recognized as a key modern turning point in Hulk history.