Lady Death: Lost Souls is a crossover event that brings together several iconic female characters from the indie comic scene. Set in 1100 AD, the story unfolds as:

The Unholy, a group of ancient demonic gods, descend upon Earth to extinguish all hope and life.

The narrative introduces five central characters:

Lady Death: The embodiment of death, known for her formidable powers.

Satasha: A master spellcaster.

War Angel: A fallen angel with a rebellious streak.

Pandora: An immortal demon hunter.

The UnHoly: An innocent female member of the demonic group.

As the story progresses, tensions rise between Lady Death, War Angel, and Pandora, leading to internal and external conflicts. Amidst the chaos, Satasha emerges as a voice of reason, attempting to mediate and guide the group through the impending doom.