Lady Death: Lost Souls is a crossover event that brings together several iconic female characters from the indie comic scene. Set in 1100 AD, the story unfolds as:

The Unholy, a group of ancient demonic gods, descend upon Earth to extinguish all hope and life.

The narrative introduces five central characters:

Lady Death: The embodiment of death, known for her formidable powers.

Satasha: A master spellcaster.

War Angel: A fallen angel with a rebellious streak.

Pandora: An immortal demon hunter.

The UnHoly: An innocent female member of the demonic group.