This issue is part of the Decimation event that followed the House of M storyline. It features the second installment of the "Childhood's End" arc, written by Craig Kyle and Christopher Yost, with art by Mark Brooks.

In this storyline, the Xavier Institute faces upheaval after many mutants lose their powers. The arrival of X-23 at the school adds complexity, while the reemergence of the Purifiers, led by William Stryker, introduces new threats. The narrative delves into themes of loss, identity, and resilience as the young mutants navigate these challenges.