Supreme Sacrifice #1 serves as a reimagining of the classic Supreme character, blending elements from Alan Moore's original run with new narratives. The issue is structured as a flip-book, featuring two distinct stories:

1st. - Robert Kirkman's Story: This segment presents Supreme confronting a horrific cult, leading to a violent and unsettling encounter that challenges his moral compass.

2nd - Rob Liefeld's Story: The flip side introduces Suprema, Supreme's counterpart, who faces multiple alternate versions of herself, exploring themes of identity and the Supremacy.

The Wizard World Los Angeles School Girl Variant cover, illustrated by Rob Liefeld, adds a distinctive visual appeal to this issue.