Humanity's existence under the reign of the House of M is bleak. The Parker family prospered because for years the world thought that Spider-Man must be a mutant. Now, exposed as a human, Peter Parker has lost everything. Wrought with guilt at having passed as a mutant when so many suffer, Peter suffered a psychotic break, leading to the 'Green Goblin' who presented Peter's journal to Jameson.

But now that he is no longer above the oppression humanity feels under the House of M, what can he do to stop it?