This issue reimagines the origin of Jessica Drew, the original Spider-Woman, providing a modernized backstory that aligns with her role in the New Avengers.

Set 30 years prior on Wundagore Mountain, scientists Jonathan and Miriam Drew are conducting genetic research. Miriam discovers a rare spider species, Latrodectus Wundagore, which Jonathan uses in his experiments. During a demonstration of a DNA compiler to General Wyndham, the device malfunctions, exposing Miriam to a large dose of radiation. This incident sets the stage for Jessica's unique abilities.

This five-issue limited series delves into Jessica Drew's transformation from a child experiment to a HYDRA agent, S.H.I.E.L.D. operative, and eventually, a superhero. The narrative explores her complex relationships and the events that shape her path to becoming Spider-Woman.