AN ALL-NEW SISTERHOOD! The X-Men have taken down super villains, aliens and their own future selves, but never all at the same time! Lady Deathstrike has put together an all new Sisterhood, her own Illuminati to take down the X-Men and take over the world. Recruiting the likes of Typhoid Mary and Enchantress, her cabal go on a global hunt for the most powerful of them allan enemy who holds the X-Men responsible for her almost-destruction. Meanwhile, M settles in and Rachel comes to terms with her relationship with Sublime.