Straight off the shocking events of last month's I, VAMPIRE #6, vampires across the world have gone berserk, attacking anyone and everyone with a pulse. Fearing her apocalyptic vision of the future has come to pass, Madame Xanadu mobilizes the team to intervene. But everything the JL Dark members know about how to slay a vampire is useless, for the world has changed. It's a crossover that had to be, continuing into this month's I, VAMPIRE #7!