In this issue, journalist Sally Floyd continues her "Mutant Diaries" column, documenting the lives of mutants who lost their powers on M-Day. She focuses on Frederick J. Dukes, formerly known as the Blob, who is struggling with his new powerless state. As Sally delves deeper into these stories, she becomes the target of a mysterious figure known as the Ghoul, who is murdering depowered mutants and wants Sally to tell his story. The tension escalates as Sally receives threats, and the line between reporting and personal involvement blurs. This issue highlights the vulnerability of former mutants and the dangers they face in a world that no longer fears them.

Generation M is a five-issue limited series that provides a human perspective on the consequences of M-Day, offering a poignant look at loss, identity, and the struggle to find purpose in a changed world.