This issue marks the beginning of the "Childhood's End" storyline, set in the aftermath of the "House of M" event. The narrative focuses on the young mutants at the Xavier Institute as they grapple with the loss of their powers and the challenges that come with a world that has drastically changed for mutants.

This issue is notable for its exploration of the emotional and psychological impact of the Decimation event on young mutants, setting the tone for the subsequent issues in the "Childhood's End" arc.