In this pivotal issue, Danielle "Dani" Baptiste, the new bearer of the Witchblade, confronts her most formidable challenge yet. The deranged Celestine Wright unleashes her full fury upon Dani, testing the limits of Dani's control over the Witchblade's immense power. As the battle intensifies, Dani must harness the artifact's strength without succumbing to overwhelming influence.

Simultaneously, Sara Pezzini, the former Witchblade wielder, approaches the final stages of her pregnancy. Her impending childbirth adds urgency to the unfolding events, setting the stage for the upcoming First Born crossover event.

The issue also features a backup story titled "New Arrival, Part 2", which delves into the legacy of the Witchblade in feudal Japan. Yuka-chan, the chosen successor of Shidori-sama, grapples with mastering the Witchblade amidst looming threats, drawing parallels to Dani's contemporary struggles.