The Thunderbolts are in town, and Venom has attacked the F.E.A.S.T. shelter where Peter's Aunt May spends her time. But a strange reaction in Eddie Brock, triggered by the close proximity of the symbiote he once bore, has transformed him into Anti-Venom. The two begin to fight even before Spider-Man arrives on the scene.

There's no love lost between any of the three, leading to a tense standoff. And which glider-riding villain is harassing mayoral candidate Bill Hollister?