The Fantastic Four are in trouble, and the only ones who can help are the world's best known and respected pair of superheroes: Spider-Man and Flash Thompson. Once the pair makes quick work of Dr. Doom, Blastaar and Annihilus, they greet their adoring fans. For a moment, Flash feels as though something is wrong. This feeling is shared by Peter Parker, who is bound to a wheelchair and living with his aunt May and uncle Ben.