The titular anti-heroine embarks on a quest for vengeance against a weapons maker who has wronged her. However, her pursuit leads her into a horrifying and inescapable situation, plunging her into a realm of pure horror. The story is illustrated by Wellington Alves and showcases Lady Death confronting terrifying challenges that test her resolve and strength. Additionally, this issue includes a special preview of the upcoming 2007 series Lady Death: Sacrilege, featuring artwork by Daniel HDR.

For collectors and fans, Lady Death: Dark Horizons was later reprinted in full color as part of the 64-page Lady Death: Apocalypse #0 special edition, released on September 15, 2015. This edition also featured a new story titled “Merciful Fate” and an extensive gallery of artwork from various artists .