In this zero issue, readers are introduced to the shadowy world of Hunter-Killers—elite operatives trained to hunt and neutralize genetically enhanced “Ultra Sapiens” who operate outside government control. The story centers on Wolf, a field agent with a lethal skillset, and Samantha Argent, a tactical commander trying to keep the world safe from rogue enhanced humans.

The issue sets the tone for the series with fast-paced action, covert military operations, and government conspiracies. It also introduces key players in the Top Cow shared universe, setting the stage for a larger conflict between those who created the Ultras and those who seek to control or destroy them.