When a small-time informant named Nose Norton disappears, Spider-Man follows the trail into the seedy underbelly of New York’s waterfront. His investigation draws the attention of the deadly Tarantula, a South American assassin armed with razor-tipped boots and acrobatic skill to match the wall-crawler’s. Meanwhile, Daily Bugle reporter Lance Bannon hunts the same story for the paper, putting himself directly in harm’s way. As Spider-Man fights to uncover who silenced Nose Norton, he finds himself battling both organized crime and the Tarantula’s ruthless ambition.